The enzyme homogentisate oxidase is responsible for the degradation of the amino acid phenylalanine. When the proline residue at position 230 is changed to serine, the protein is non-functional, causing a genetic disease. i) What genetic disease is caused by mutations in this enzyme? What are the symptoms (Web-work)? ii) The structure of the wild-type enzyme at the site of the mutation is shown on the right. The arrow indicates the proline at residue 230, buried in the core of the protein. Based on your knowledge of protein structure, why might changing this residue to serine lead to destabilization of the enzyme and loss of function?