Question

The free energy change for ATP hydrolysis is -30.5 kJ/mol under standard conditions, but the actual free energy of hydrolysis (ΔG'°) of ATP in living cells is very different because the cellular concentrations of ATP, ADP, and Pi are not identical and are much lower than the 1.0 M of standard conditions. The actual free energy of hydrolysis of ATP under intracellular conditions is often called its phosphorylation potential, ΔGp. Calculate the actual free energy of hydrolysis of ATP, ΔGp, in human erythrocytes at pH 7.0 and the temperature 37°C (body temp). The concentrations of ATP, ADP, and Pi in human erythrocytes are 2.25, 0.25, and 1.65 mM, respectively. Hint: ΔGp = ΔG'° + RT ln [ADP][Pi]/[ATP] What does this reveal about the amount of energy required to synthesize ATP under the physiological conditions?

          The free energy change for ATP hydrolysis is -30.5 kJ/mol under standard conditions, but the actual free energy of hydrolysis (ΔG'°) of ATP in living cells is very different because the cellular concentrations of ATP, ADP, and Pi are not identical and are much lower than the 1.0 M of standard conditions. The actual free energy of hydrolysis of ATP under intracellular conditions is often called its phosphorylation potential, ΔGp.
Calculate the actual free energy of hydrolysis of ATP, ΔGp, in human erythrocytes at pH 7.0 and the temperature 37°C (body temp). The concentrations of ATP, ADP, and Pi in human erythrocytes are 2.25, 0.25, and 1.65 mM, respectively.
Hint: ΔGp = ΔG'° + RT ln [ADP][Pi]/[ATP]
What does this reveal about the amount of energy required to synthesize ATP under the physiological conditions?

Added by F-Tima R.

Question

Please give Ace some feedback