The hydrolysis of Adenine Triphosphate, ATP, to adenine diphosphate, ADP, and phosphate, Pi, is an important biological reaction which is often coupled to non-spontaneous reactions to enable them to occur. Under standard conditions:
ATP + H2O → ADP + H+ + Pi ΔrG°(298 K) = -30.5 kJ mol-1
Which of the following reactions CAN NOT be coupled to ATP hydrolysis to make them spontaneous (under standard conditions)?
(A) Glucose + Pi → Glucose-6-P + H2O ΔrG°(298 K) = +13.8 kJ mol-1
(B) Glycerol + Pi → Glycerol-3-P + H2O ΔrG°(298 K) = +9.2 kJ mol-1
(C) Creatine + Pi → Phosphocreatine + H2O ΔrG°(298 K) = +43.0 kJ mol-1
(D) Fructose + Pi → Fructose-6-P + H2O ΔrG°(298 K) = +15.9 kJ mol-1