Incorrect Question 13 0 / 1 pts Consider the Sonic hedgehog (SHH) signaling pathway depicted below. What would happen to the cell if a mutation occurred in the gene coding for Cos2, causing Cos2 to lose its ability to tether Gli to microtubules in the primary cilium? Sonic hedgehog (SHH) signaling pathway No SHH ligand SHH ligand present Vertebrate Microtubule SuFu Smoothened Primary Hedgehog Gli Cos2/ Kif7 cilium Boc/Cdo Gas1 Cos2/ Kif7 Patched SuFu Gli PKA Smoothened Gli repressor No transcription of Hedgehog-responsive genes Gli Degradation Gli activator Gli Transcription of Hedgehog-responsive genes Gli activators would constantly be turning on Sonic hedgehog-responsive genes Patched receptor would be unable to bind Sonic hedgehog (SHH) ligand Smoothened would be unable to travel into the primary cilium Gli repressors would constantly block transcription of Sonic hedgehog-responsive genes Barresi 12e, fig 4.24
Added by Christina J.
Close
Step 1
In the normal Sonic hedgehog (SHH) signaling pathway, the SHH ligand is present and binds to the Patched receptor. Show more…
Show all steps
Your feedback will help us improve your experience
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
1. What proteins operate in the Sonic hedgehog signal transduction pathway and how do they interact with each other? 2. If Sonic hedgehog were normal but one of the other proteins in the Shh signal transduction cascade were rendered non-functional due to a mutation, what effect would you expect to see in the infant? 3. Why might problems with cholesterol biosynthesis potentially lead to holoprosencephaly? 4. What goes wrong during early brain development to cause holoprosencephaly? 5. What evidence is there that mutations in Sonic hedgehog can in fact cause holoprosencephaly? Is it convincing? 6. In a discussion with the mother after the birth of the child, Dr. Reed asked if the mother had diabetes or if she had consumed any alcohol during pregnancy. Why did Dr. Reed want to know this information? 7. Is it likely that there are other possible causes for holoprosencephaly other than Sonic hedgehog? 8. Will our knowledge of the role of Sonic hedgehog in holoprosencephaly lead to a cure or a way to prevent this from happening? What would be the complicating factors in developing a way to cure holoprosencephaly? 9. Frequently, several members of a "holoprosencephaly family" who carry the mutant gene will appear completely normal. How might this affect the counseling of these potential parents about their reproductive risks? Might an understanding of these risks make it more or less likely that they would agree to participate in a study?
Madhur L.
2. If Sonic hedgehog were normal but one of the other proteins in the Shh signal transduction cascade were rendered non-functional due to a mutation, what effect would you expect to see in the infant?
BMP signaling is embedded within a larger network of signaling pathways that act coordinately to control vertebrate limb development. The complex interactions between different signaling pathways are difficult to dissect and are the focus of ongoing research. The researcher that you collaborate with is currently working on the sonic hedgehog signaling pathway. Although the sonic hedgehog (Shh) ligand is not expressed in the developing vertebrate limb, the researcher has hypothesized that active sonic hedgehog signaling could induce gremlin expression in interdigital cells. Describe an experiment using chick or duck embryos that could be used to test this hypothesis.
Dennis H.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Watch the video solution with this free unlock.
EMAIL
PASSWORD