The ligand molecule for the ion channel-coupled receptor is Neurotransmitter K+ Na+
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Step 1: Define the terms — a ligand is a molecule that binds to a receptor and causes a change in the receptor's activity; an ion channel-coupled receptor (ligand-gated ion channel) is a receptor that opens or closes an ion-conducting pore in response to a bound Show more…
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Ligand binding of a ligand causes conformational changes in the receptor that free the associated G-protein to interact with other membrane proteins. Voltage-gated ion channel GPCR Ligand-gated ion channel Ligand-gated pore
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Neurotransmitters open ion channels in the postsynaptic cell causing the cell membrane to depolarize and an excitatory postsynaptic potential (EPSP) is produced in the next nerve cell. Neurotransmitters diffuse across the synaptic cleft and bind to receptors embedded in the postsynaptic cell membrane. Ligand-gated potassium channels open resulting in depolarization of the membrane. Voltage-gated Ca2+ channels open. Ca2+ moves across the cell membrane and into the cytosol. Intracellular Ca2+ binds to vesicles and triggers the release of neurotransmitters into the synaptic cleft via exocytosis. Neurotransmitter molecules are removed from the synaptic cleft. They are either taken up by the presynaptic cell or are degraded by enzymes.
Ligands that activate channels from the cytoplasmic side of the membrane include [A] and [B] [A] : Calcium [B]: ????
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