00:02
Hello, according to the question, once methylation done, methylation done, then mgmt cytosine gets turned off.
00:21
Once it get turned off, they will not take participation in repairing dna damage in cancer cell.
00:47
Now move to the next question.
00:52
So if mgmt promoting.
00:55
Motor gets unmithylated, then dna is transcribed into mrna and mrn is transcribed into proteins mgmt mgmt proteins right and these proteins are responsible in repairing dna damage dna damage, dna damage right? caused by chemo, right? once if mgmt promoter gets methylated, gets methylated, then there is no transcription, no translation and no formation of mgmt proteins, right? so that means there is no repairing of dna damage, no repairing of dna damage.
02:13
Then in that case chemo can kill the cancer cells.
02:19
Now move to the question 3.
02:22
The answer, basically mgmt promoter, mgmt promoter, mgmt promoter, mgmt promoter, it is the key...