The ubiquitin-proteasome pathway Check All That Apply is used to regulate expression of a number of cell surface receptors requires only one molecule of ATP to target a protein targets proteins in a stepwise fashion via ubiquitin ligase adding ubiquitin residues to the protein is used to digest macromolecules does not destroy the ubiquitin moiety, but rather cleaves it off for reuse
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This pathway is a major mechanism for protein degradation in eukaryotic cells. Show more…
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Which ONE of the following statements is correct regarding the targeting of a protein by polyubiquitylation in order to signal its degradation? I. Involves covalent attachment of the target protein to the E1 enzyme. II. Is carried out by the proteasome complex. III. Requires the hydrolysis of one ATP molecule to ADP per polyubiquitin chain. IV. Involves the recognition of the target protein by an E2-E3 ligase. V. Is typically done on an arginine residue in the target protein.
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Ubiquitination is the process by which proteins are marked for degradation, and is essential for the health of the cell. Which of the following ways can be used by the cell to control when a particular protein is ubiquitinated (mark all that apply) Activation of the ubiquitination signal on the target protein Activation of a ubiquitin ligase Controlled expression of a particular E3 protein Activation of the proteasome
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