Thiamine deficiency is associated with late stage alcoholism. This vitamin is a precursor to thiamine pyrophosphate, a coenzyme for pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. Predict how this deficiency will influence the levels of key glycolytic and citric acid cycle metabolites relative to a healthy individual. Enter Decrease, Increase, or No change. Metabolite Effect of thiamine deficiency on level of metabolite Pyruvate Blank 1 Lactate Blank 2 alpha-ketoglutarate Blank 3 Succinyl CoA Blank 4
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Step 1
Thiamine (vitamin B1) is converted into thiamine pyrophosphate (TPP), which is a coenzyme for several important enzymes, including pyruvate dehydrogenase and α-ketoglutarate dehydrogenase. These enzymes are crucial for the conversion of pyruvate to acetyl-CoA and Show more…
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