Translocation of pieces of chromosomes 9 and 22 form a fusion gene that is associated with chronic myelogenous leukemia pancreatic cancerO thyroid cancer Burkitt's lymphoma
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Which of the following is true regarding the cause of Chronic myelogenous leukemia? (Philadelphia chromosome) The BCR/ABL fusion gene that results encodes for a protein with weak tyrosine kinase activity. It is the result of a reciprocal translocation between the long arms of chromosomes 22 and 9. Chromosomal inversion that brings together the NTRK1 gene and TPM3 gene. A cytogenetic change results in the relocation of the ABL oncogene from chromosome 9 to chromosome 22.
Sri K.
The chromosome $9 / 22$ translocation associated with CML (chronic myelogenous leukemia) is called the Philadelphia chromosome after the city in which its cancer association was first discovered in 1960 . People with CML do not inherit this translocation it occurs in somatic cells. Why do you think that this particular translocation that fuses the $b c r$ and $a b l$ genes happens independently in the somatic cells of many different people?
BCR-ABL gene fusion is a common gene translocation in chronic myelogenous leukemia. This translocation (as shown in the diagram) generates an oncoprotein that contains one portion of the BCR and ABL proteins. For example, we know that such a translocation occurred in 1 out of 3 leukemia tumor samples. Do you have any approaches to define which tumor has the translocation? Please describe at least two strategies.
Suman K.
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