00:01
Okay, i want to answer this question.
00:01
Let's talk about a negative feedback loop.
00:05
Remember that in case of thyroid hormones, the hypothalamus, the hyposalamus is going to secrete a hormone that is called trh.
00:16
Trh, okay? and this trh is going to go to the pituitary gland, specifically to the anterior pituitary gland, and it is going to stimulate it in order to produce a hormone called tsa.
00:29
This t .s .h is then going to be released to the blood, and it is going to the thyroid gland in order to stimulate the production of t3 and t4, that in general you can see them as thyroid hormone.
00:42
For example, remember that this thyroid hormones require iodine in order to be produced in the thyroid gland.
00:50
If you have low levels of iodine, then you are not going to be able to synthesize these hormones in the thyroid gland even when you have normal levels of the acid.
00:59
So when you have low levels of these hormones here, your hypothalamus is going to sense these low levels of hyrormons.
01:08
So it is going to work more and it is going to produce more or it is going to stimulate more the anterioropitheatory gland in order to produce more thysh.
01:18
So this thesh is going to be produced in the anterioropitheotary gland and it is going to go and act practically on the thyroid gland in order to produce more levels of thyroid gland.
01:30
Glands, thyroid hormones, i'm sorry, but as a thyroid gland cannot produce more higher hormones because there is no iodine practically available, then the thyroid gland is going to be very stimulated because stimulation is going to cure, but what is not going to happen is that these hormones are going to be produced, okay? so, if this is your thyroid gland cell, for example, and this is the receptor for tsa, and you have here tsh, tsa is going to bind two receptors on the thyroid gland.
02:00
But what is not going to happen is that this hormones are not going to be produced, but anyway, that thyroid is going to be stimulated, and this can cause goiter if there is too much stimulation by tsa to the thyroid.
02:14
So let's look at the first sentence.
02:17
It says that goiter oniosis, thyroid was caused by a nutritional deficiency of the element.
02:22
And this blank number one is going to be, it's not going to be tsa.
02:25
Okay, it is going to be iodine.
02:28
So this is the answer for blank number one.
02:33
Then we have without this element, the product of hormone by the blank was significantly diminished...