Use the following information to answer the next question
Sarin is a chemical with the compound C4H10FO2P that was initially developed in
1938 as a pesticide, then later used as a chemical war agent during WWII. Sarin
works by disrupting the function of acetylcholinesterase, which breaks down
acetylcholine in the neuro-muscular synapse. It causes symptoms such as involuntary
muscle contractions, difficulty breathing, and uncontrollable coughing.
5. Based on the information above, what can we deduce about the function of
acetylcholinesterase (AChE) and acetylcholine (ACh)in the neuro-muscular
junction?
ACh is an inhibitory neurotransmitter, which hyper-polarizes the muscle cell.
Inhibiting AChE causes excessive hyper-polarization of the cell, therefore
decreasing the ability for voluntary muscle contraction.
ACh is an modulatory neurotransmitter, which increases the sensitivity of
muscle cells to action potentials by decreasing polarization. Inhibiting AChE
causes hyper-sensitivity of muscle cells to action potentials, therefore
causing involuntary muscle contractions.
ACh is an excitatory neurotransmitter, triggering action potentials. Inhibiting
AChE causes insufficient ACh release into the synapse, therefore blocking
voluntary muscle contractions.
ACh is an excitatory neurotransmitter, triggering action potentials. Inhibiting
AChE triggers continuous action potentials to muscle cells, therefore causing
uncontrolled contractions.