Use the following information to answer the next question. Tay-Sachs disease is a hereditary disease that kills 1 in 360 000 individuals in the general population. Children who are homozygous for Tay-Sachs disease die at an early age. Genetic screening can be done to determine if an individual is a carrier of the Tay-Sachs allele. Genetic screening can involve producing complementary DNA probes of a gene's alleles and determining if these bind to an individual's DNA sample. Genetic screening results show that an individual is a carrier of Tay-Sachs disease if the individual's DNA binds to... Select one: A. none of the DNA probes B. two of the normal allele DNA probes C. one of the normal allele DNA probes and one of the defective allele DNA probes D. two of the defective allele DNA probes
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Tay-Sachs disease is a hereditary disease that is caused by a defective allele. Show more…
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Tay-Sachs disease is a hereditary disease that kills 1 in 360,000 individuals in the general population. Children who are homozygous for Tay-Sachs disease die at an early age. Genetic screening can be done to determine if an individual is a carrier of the Tay-Sachs allele. Genetic screening can involve producing complementary DNA probes of gene alleles and determining if these bind to an individual's DNA sample. Genetic screening results show that an individual is a carrier of Tay-Sachs disease if the individual's DNA binds to: - None of the DNA probes - Two of the normal allele DNA probes - One of the normal allele DNA probes and one of the defective allele DNA probes - Two of the defective allele DNA probes
Madhur L.
Tay-Sachs disease is caused by a recessively inherited mutation in the gene coding for the enzyme hexosaminidase $\mathrm{A}(\mathrm{HEXA}),$ which normally breaks down a lipid called GM2 ganglioside. Accumulation of this lipid in the brain leads to progressive deterioration of the nervous system and death, usually by age $4 .$ HEXA activity in blood serum is 0 to 6 percent in homozygous recessives and 7 to 35 percent in heterozygous carriers, compared with non-carriers (100 percent). The most common mutation in the $H E X A$ gene is an insertion of four base pairs, which presumably leads to a premature stop codon. How would you do genetic screening for carriers of this disease by enzyme testing and by DNA testing? What are the advantages of DNA testing? How would you investigate the premature stop codon hypothesis?
Tay-Sachs disease is an inherited genetic disorder in which the gene sequence codes for an enzyme involved in lipid metabolism. Accumulation of lipids in the brain leads to seizures, blindness, loss of neural function, and early death. People can be carriers of this disease, and only homozygotic offspring will die from this disorder. When the enzyme structure of a heterozygote carrier is examined, there is an equal number of functioning and non-functioning enzymes produced. This is an example of
Jennifer H.
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