Question 3 Which of the following statements is incorrect? O DNA methylation would lead to open chromatin and gene activation. O Histone acetylation would lead to open chromatin and gene activation. O DNA methylation occurs on the cytosine nucleotide. O Histone methylation occurs on the Lysine and Arginine residues. < Previous No new data to save. Last checked at 11:56
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Let's analyze each statement: Statement 1: "DNA methylation would lead to open chromatin and gene activation." DNA methylation typically involves the addition of a methyl group to the cytosine base, often in CpG islands. This modification is generally associated Show moreā¦
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a. Histone acetylation results in the activation of gene expression because this modification neutralizes the charges and decreases the affinity of positively charged histone tails for the negatively charged DNA molecules. b. Histone methylation occurs mainly on the arginine and lysine residues of histones H3 and H4 and can result in either gene activation or repression. During this modification, one or several groups can be added to the residue. c. Histone phosphorylation takes place on serine, threonine, or tyrosine residues of histones. This modification adds an extra negative charge to the histones.
Sri K.
The following questions are related to chromatin modifications. Select TRUE if the statement is correct, otherwise select FALSE. Histone acetylation neutralizes negative histone charges and results in more loosely packed chromatin. In honeybees, the royal jelly inhibits Dnmt3, causes less DNA methylation. DNA methylation can either increase or decrease expression. The epigenetic marks occur during X inactivation is H3K27 methylation. Jpx stimulates the transcription of Xist in the inactive chromosome while Tsix inhibits it. Histone tails that are acetylated on lysine 9 (H3K9 acetylation) are typically found in constitutive heterochromatin.
Which of the following statements about epigenetic modification is INCORRECT? Select one alternative: Methylation of DNA and histones causes nucleosomes to pack tightly together. Histone acetylation results in the loose packing of nucleosomes. Epigenetic modifications can be passed on to future generations. Epigenetic modification alters the sequence of nucleotides in the DNA.
Aparna S.
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