What is the factor for SXL gene? Addon: if the SXL gene is removed, will the male or female get affected?
Added by Andrea O.
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The SXL gene (Sex-lethal) is a key sex-determination gene in Drosophila (fruit flies). It acts as a master regulatory gene controlling female development by regulating alternative splicing of downstream genes. Show more…
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Figure 17.29 shows that the Sxl protein binds to the mRNA of the $m s l-2$ gene, inhibiting translation of the mRNA's proper reading frame. The MSL-2 protein is a transcription factor that binds to the X chromosome in $\mathrm{XY}$ males to double the level of $\mathrm{X}$ -linked gene transcription, thus equalizing X-linked gene expression in $\mathrm{XY}$ males and $\mathrm{XX}$ females. a. In which sex, $\mathrm{XY}$ males or $\mathrm{XX}$ females, would the Sxl protein bind to the $m s l-2$ mRNA? b. As discussed in Problem $41,$ some $S x l$ alleles are lethal to females and others are lethal to males. Is the function of Sxl in regulating the synthesis of Msl-2 protein sufficient to explain the sex-specific lethality caused by both kinds of alleles? c. Predict the effect of loss-of-function mutations in $m s l-2$ on male and female fertility and viability.
Sex-lethal (Sxl) is the sex determination master switch that controls somatic sexual development in Drosophila. Discuss the different levels of Sxl gene regulation in early and late development in both females and males. What phenotype would be predicted if the Sxl gene was deleted? Explain your answer.
Sri K.
In the sex determination system found in Drosophila, what does the Sxl (Sex lethal) gene do? A. When expressed (On) initiates female development. B. When expressed (On) initiates male development. C. Is lethal if expressed. D. Blocks the expression of sisterless genes. E. Counts the number of X chromosomes. F. Counts the number of autosomes. Which statement is true about the pseudo-autosomal region (PAR)? A. The PAR is a region on the Y but also on an autosome. B. The PAR is never involved in recombination. C. The PAR carries sex determining genes. D. The PAR is found only on the Y chromosome in mammals. Which is true about this statement. Trisomics occur and survive to adulthood in humans. A. Yes but Downs syndrome is the only example. B. Yes but 3N = 69 is unbalanced and causes major developmental problems. C. Yes but none of the other statements is correct. D. Never. E. Yes but only for 2N = 47 (+X).
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