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What is/are the key post-translational modification(s) on IκB that result in its release from NF-κB and subsequent degradation? - Addition of phospholipids to its C-terminal domain - Phosphorylation and polyubiquitination - Phosphorylation and monoubiquitination - Only phosphorylation - None of the above

          What is/are the key post-translational modification(s) on IκB that result in its release from NF-κB and subsequent degradation?
- Addition of phospholipids to its C-terminal domain
- Phosphorylation and polyubiquitination
- Phosphorylation and monoubiquitination
- Only phosphorylation
- None of the above
        
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Added by Emily R.

Biology for AP Courses
Biology for AP Courses
Julianne Zedalis, John Eggebrecht
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What is/are the key post-translational modification(s) on IκB that result in its release from NF-κB and subsequent degradation? - Addition of phospholipids to its C-terminal domain - Phosphorylation and polyubiquitination - Phosphorylation and monoubiquitination - Only phosphorylation - None of the above
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Transcript

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00:01 In this video i'm going to talk a little bit about the role of alternative splicing in gene regulation.
00:13 On the left, you can see a little reminder of the different levels of gene regulation.
00:19 An alternative splicing is a post -transcriptional method of control.
00:27 This is the stage where rna processing happens.
00:34 And the primary transcript, which is basically the freshly made rna molecule, is modified.
00:47 By splicing and by other methods such as adding a cap on the end.
00:52 But spicing is what we're interested in.
00:56 During splicing, there's the removal of introns and the remaining exons are linked.
01:14 Now, with alternative splicing, the idea is that a different combination of exons can be spliced together.
01:25 Let me show you an example.
01:28 If this is our primary transcript, and here we have exxon 1, an intron, xon 2, another intron, and so forth...
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