When a typical protease (not from the ubiquitin system) is synthesized by the ribosome, it generally is in an inactive form until it is moved to the organelle in which it operates. Describe two of several means (5 points ea.) by which they are kept inactive, and how and why it becomes activated upon delivery to this protease-packed organelle (5 points).
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The propeptide sterically blocks the substrate-binding cleft and/or holds the catalytic residues in an inactive geometry and often acts as an intramolecular chaperone to assist folding and trafficking. Example molecular details: in many serine proteases cleavage Show more…
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When a typical protease (not from the ubiquitin system) is synthesized by the ribosome, it generally is in an inactive form until it is moved to the organelle in which it operates. Describe two of several means (5 points each) by which they are kept inactive, and how and why it becomes activated upon delivery to this protease-packed organelle (5 points).
Madhur L.
Ribosomes in the cytoplasm (cytosol) capture mRNA that can be translated into an enzyme (in this case a protease) to the lysosome. a) Describe what happens from the time the enzyme (protease) begins to form in the cytoplasm until it end up in the lysosome and explain how the enzyme is transported to the lysosome.
Sri K.
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