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When two genes are linked but are quite far apart so that crossing over occurs, their estimated map distance, based on recombination frequencies, is often an underestimation of their true map distance. What is the explanation for this underestimation? O The genes are located on different pairs of homologous chromosomes. O Some double crossover events go undetected since they do not lead to recombinant progeny. O There will be more single crossover events counted than actually have occurred, so the recombination frequencies will be reduced. o One of the genes is lethal when homozygous, which reduces the recombination frequency.

          When two genes are linked but are quite far apart so that crossing over occurs, their estimated map distance, based on recombination frequencies, is often an underestimation of their true map distance. What is the explanation for this underestimation? O The genes are located on different pairs of homologous chromosomes. O Some double crossover events go undetected since they do not lead to recombinant progeny. O There will be more single crossover events counted than actually have occurred, so the recombination frequencies will be reduced. o One of the genes is lethal when homozygous, which reduces the recombination frequency.
        
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Biology for AP Courses
Biology for AP Courses
Julianne Zedalis, John Eggebrecht
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When two genes are linked but are quite far apart so that crossing over occurs, their estimated map distance, based on recombination frequencies, is often an underestimation of their true map distance. What is the explanation for this underestimation? O The genes are located on different pairs of homologous chromosomes. O Some double crossover events go undetected since they do not lead to recombinant progeny. O There will be more single crossover events counted than actually have occurred, so the recombination frequencies will be reduced. o One of the genes is lethal when homozygous, which reduces the recombination frequency.
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Genetic maps are based on recombination frequencies. However, because some multiple crossovers produce parental rather than recombinant gametes, as the physical distance between two loci increases, the maximum recombination frequency levels off at 50%. But suppose you discovered a species where the location of each crossover event occurs at random but there is only one crossover per chromosome and no multiple crossovers occur. In this case, as the physical distance between two loci increases, you would expect the recombination frequency to

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00:01 Okay, so to explain this question, we need to understand a few points.
00:13 Right.
00:14 Now, we know that recombination frequency, recombination frequency is equal to number of recombinant progeny, number of recombinant progeny, divided by total number of progeny...
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