Which may be the reason for the mental retardation and ataxia observed in Angelman syndrome? Removal of single active paternal chromosome copy of a gene that encodes ligase. Removal of single active maternal chromosome copy of a gene that encodes ligase. Presence of single active paternal chromosome copy of a gene that encodes ligase. Presence of single active maternal chromosome copy of a gene that encodes ligase.
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Step 1: Angelman syndrome is a neurogenetic disorder caused by a deletion or inactivation of the maternal copy of the UBE3A gene on chromosome 15. Show more…
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Place a single word in each sentence to make it correct. The genes that cause Prader-Willi syndrome and Angelman syndrome are closely linked on chromosome ________. A person develops Prader-Willi syndrome if they are missing a functional copy of a gene inherited from their ________. A person develops Angelman syndrome if they are missing a function copy of a gene inherited from their ________. The process of ________ involves differential expression of the genes inherited maternally and paternally. Typically differential expression occurs due to a differentially ________ region located near the genes. Imprinting is an example of ________ inheritance because gene expression is modified but the nucleotide sequence is not. extranuclear father five fifteen mother epigenetic imprinting methylated acetylated Reset
Madhur L.
Which one of the following statements is incorrect about the location and function of genes in higher eukaryotes, e.g. human beings? Different proteins are expressed in different cells because some cells contain the genes for certain proteins and others do not. Genes are located on chromosomes and mitochondrial DNA. Different cell types can be produced by regulating which genes are expressed and which are not. Histones have several major roles in the cell. Which of the following correctly describes histones? DNA is wrapped around them, so that it can be packaged to fit into the nucleus. Their association with DNA is involved in controlling when transcription of genes occurs. They are found in eukaryotes. All of the above. Transcription factors can either activate or repress gene expression. From the list below which of the following will most likely result in activation of gene expression? Transcription factors that block access to an enhancer. Transcription factors that destabilize the interaction between RNA polymerase and the promoter. The binding of a transcription factor near the promoter triggering histone acetylation. A repressor protein that interacts with a transcription factor bound to an enhancer, preventing it from recruiting general transcription factors. The binding of a transcription factor near the promoter triggering histone deacetylation. In eukaryotes a particular single primary mRNA can result in two different active proteins (i.e. their amino acid sequences are not identical). Which of the following could produce two different active proteins originating from one primary transcript? Imprinting. X-inactivation. RNA editing. Chromatin remodeling. Igf2 encodes a hormone required for embryonic development and is located on an autosome (not a sex chromosome). It is critical that only one copy of the Igf2 gene is expressed as expression from both copies results in too much active hormone. More active hormone than normal could be caused by one of the following: Removal of the Igf2 promoter for the maternal Igf2 gene. A mutation that reduces methylation of the maternal Igf2 gene. A mutation that increases methylation of the maternal Igf2 gene. A repressor binding to a silencer near the maternal Igf2 gene.
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