Which of the following best describes the interaction between histones and DNA? Histones only bind to RNA during transcription Histones bind to specific DNA sequences based on base pairing Histones bind to negatively charged phosphate groups of DNA Histones are repelled by DNA due to their negative charge
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Step 1: Histones are positively charged proteins that bind to negatively charged DNA. Show more…
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Why do histones bind tightly to DNA? Histones are covalently linked to the DNA Histones are positively charged, and DNA is negatively charged. Histones are highly hydrophobic; and DNA is hydrophilic, Histones are negatively charged, and DNA is positively charged. Both histones and DNA are strongly hydrophobic.
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Which of the following statements about histones is FALSE A. Positively charged amino acids on histones contact the negatively charged phosphates on the DNA backbone. B. Adding acetyl groups to specific amino acids on histones can change the condensation state of chromatin. C. Histones are highly conserved, basic proteins. D. About 150bp of DNA is wound around eight histone proteins to form a nucleosome. E. Histones in a nucleosome make many close contacts with DNA bases in the major groove.
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Histones are proteins that bind to DNA in eukaryotes, promoting the folding of DNA into tightly packed chromatin (this in turn can have important consequences for expression of genes). The sugar-phosphate backbone is negatively charged due to Oxygen atoms (of the phosphate groups within a phosphodiester bond). The pI of histones is very high (~11). A) What amino acid residues do you think are particularly enriched in histones, which specifically are contributing to such a high pI? B) How would these same amino acid residues (that are contributing to a high pI) contribute to strong binding of histone proteins to DNA?
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