Which of the following is a characteristic of B-2 cells? ? They are located primarily in secondary lymphoid organs. ? They comprise only 5% of the B-cell repertoire ? In adults, they are renewed by cell division in the peripheral circulation. ? They are not dependent on T helper cells for activation.
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Part A Select the false statement(s) regarding B cell receptors. They are complementary in shape to a specific antigenic determinant that they may or may not encounter. Each B lymphocyte is randomly generated with antibody variable regions that determine its BCR. Scientists estimate that each person forms approximately 10¹¹ different types of B lymphocytes with distinct BCRs. They are bound to the surface of B lymphocytes and have two antigen-binding sites. They are formed in response to an encounter with an antigen.
Madhur L.
Single Choice 1. Which cells are rapidly dividing B cells located in the dark zone of germinal centers? (A) centroblasts (B) centrocytes (C) plasmablasts (D) plasma cells 2. Which of the following molecular can NOT be detected on the surface of pre-B cells? (A) IL-7Ȓ (B) ̐ or ̑ chain (C) ̑ chain (D) surrogate light chain 3. Which of the following is a characteristic of follicular dendritic cells in the primary follicles lymphoid tissues? (A) They provide a stable depository of intact antigens able to bind to B-cell receptors. (B) They internalize immune complexes through CR2 receptor cross-linking. (C) They bear bundles of immune complexes called iccosomes that are passed on to antigen- (D) They produce cytokines that induce B cells to proliferate and become centroblasts.
Adi S.
Which statement is NOT correct regarding the fate of B-2 cells during or after activation? (Choose only one) 1) Activated B cells can either enter the primary foci or the germinal center. 2) B cells upregulate CCR7 after antigen processing, and CCR7 directs antigen-experienced B cells to the T cell-rich areas, allowing for the cognate B and Th cell interaction. 3) Follicular dendritic cells (FDC) are professional antigen-presenting cells that process and present protein antigen to naïve B-2 cells on MHC II molecules. 4) CD40-CD40L interaction between an activated B cell and T follicular helper (TFH) cell is required for the formation and maintenance of the germinal center.
Md.Daniyal A.
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