Which of the following is a forward transport sorting signal acting at the ER? a. diacidic amino acid motif within the cytosolic domain b. KDEL (Lys-Asp-Glu-Leu) C-terminal sequence c. KKXX (Lys-Lys-X-X) within the cytosolic domain d. NPXY (Asn-Pro-X-Tyr) within the cytosolic domain
Added by Oscar P.
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The question asks for a forward transport sorting signal acting at the ER. Forward transport refers to the movement of proteins from the ER to the Golgi apparatus. Show more…
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Which of the following statements regarding signal sequences is NOT true? Proteins modified with a mannose-6-phosphate localize exclusively to the lysosome. The KDEL receptor contains a C-terminal Lys-Lys-X-X sequence. The di-arginine sorting sequence can be located anywhere in the cytoplasmic domain of an ER-resident protein. A protein with a KDEL sequence localizes to the ER via COPI retrieval.
Md.Daniyal A.
3 A) Which of the following statements regarding signal sequences is NOT true? The di-arginine sorting sequence can be located anywhere in the cytoplasmic domain of an ER-resident protein. A protein with a KDEL sequence localizes to the ER via COPI retrieval. The KDEL receptor contains a C-terminal Lys-Lys-X-X sequence. Proteins modified with a mannose-6-phosphate localize exclusively to the lysosome. 3 B) Which of the following statements regarding clathrin-coated vesicles is FALSE? Adapter complexes provide the specificity of vesicle cargo. Membrane proteins containing a Tyr-X-X-? sequence are recruited into clathrin/AP3 coats. Clathrin-coated vesicle assembly is mediated by the GTPase ARF. Dynamin is required for pinching off clathrin-coated vesicles.
Dominador T.
A COPII vesicle sorting signal on a membrane protein destined for transport from the ER to the Golgi functions by binding luminal proteins. This requires recognition by a KDEL sequence for packaging into a COPII vesicle. The KDEL sequence functions as a luminal ER retrieval signal via its recognition by the targeting ER luminal proteins for packaging into a vesicle. The KKXX sequence functions as a membrane protein ER retrieval signal via its recognition by components of the vesicle coat, which facilitates transport from the ER. A KDEL receptor would be expected to have both the KDEL and KKXX sequences mentioned above.
Keemin L.
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