Which of the following is not true regarding the second tetrahedral intermediate in amide hydrolysis by chymotrypsin? A. This intermediate is on the pathway of an ester being converted to a carboxylic acid B. Hydrogen bonding from the imidazole of histidine assists the amino group in leaving upon collapse of the tetrahedral intermediate C. This intermediate involves the active site serine. D. This intermediate is stabilized by the oxyanion hole
Added by Erica C.
Close
Step 1
Step 1: The second tetrahedral intermediate in amide hydrolysis by chymotrypsin is formed when the carbonyl carbon of the amide bond attacks the serine residue in the active site of chymotrypsin, resulting in the formation of a tetrahedral intermediate. Show more…
Show all steps
Your feedback will help us improve your experience
Madhur L and 101 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Madhur L.
Which of the following statements is TRUE? Select one: a. SN2 reactions result in the racemic product if we start from one enantiomer of a chiral substrate. b. The SN2 mechanism does not have any intermediates and has only one transition state. c. SN1 reactions have a carbocation as an intermediate. d. Only the strength of the nucleophile is important for SN2 reactions, not the nature of the leaving group. e. Tertiary alkyl chlorides are the best substrates for SN2 reactions.
Adi S.
Which of the following is an incorrect statement about the bromination of benzene by Br2 and FeBr3? A) The carbanionic intermediate is resonance stabilized. B) Formation of the sigma complex is the rate-determining step of the mechanism. C) FeBr3 functions to increase the electrophilicity of Br2. D) The final step of the mechanism is loss of H+. E) There is one carbon-containing intermediates in the mechanism.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD