Which of the following is true of the hinge region of immunoglobulin G (IgG)? It is located at the junction between the variable and constant regions of heavy and light chains, permitting the antigen-binding sites to fold correctly. It provides flexibility that enables IgG to bind to antigens that are different distances apart on the surface of pathogens. It is the exchange site where the heavy-chain C region is switched to produce isotypes other than IgG. It is the site of highest amino acid variability in the antibody molecule.
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