Which statement about fatty acid synthesis is correct? Fatty acids cannot be synthesized from acetyl-CoA units derived from glucose. Although malonyl-CoA molecules are three carbons in length, only carbons-1 and -2 of malonyl-CoA are incorporated into fatty acids. Fatty acid synthesis reactions proceed via a repeating cycle of condensation-reduction-hydration-oxidation steps. The chain elongation reactions of fatty acid synthesis occur in the mitochondrial matrix.
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Fatty acids can indeed be synthesized from acetyl-CoA units derived from glucose, so the first statement is incorrect. Show more…
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Which statements about fatty acid metabolism are true? (Select all that apply) - The product is pyruvate, which then enters the citric acid cycle - The product is acetyl-CoA, which then enters the citric acid cycle - The product is acetyl-CoA, which then undergoes oxidative decarboxylation - The product is a short (n-2) fatty acyl-CoA, which can then re-enter the fatty acid breakdown cycle
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In comparing fatty acid biosynthesis with β-oxidation of fatty acids, which of the following statements is FALSE? Acyl-CoA derivatives are intermediates in both systems. Fatty acid biosynthesis uses NADPH, whereas β-oxidation uses NAD+ and FAD. The condensation of two moles of acetyl-CoA is more rapid in bicarbonate buffer than in phosphate buffer at the same pH; the cleavage of acetoacetyl-CoA proceeds equally well in either buffer. Fatty acid synthesis is catalyzed by cytosolic enzymes; fatty acid degradation by mitochondrial enzymes. Breakdown of a 16C fatty acid produces more than enough energy to rebuild that fatty acid.
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