Which structure is required for proteins to enter the endomembrane system? Responses transport vesicle transport vesicle microtubules microtubules signal sequence signal sequence kinesin kinesin
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Which of the following can be very easily altered to make a specific protein go to a new destination in the cell? The SRP protein The signal sequence Microtubules The Golgi vesicles
Sana R.
Vesicular-trafficking molecules cargo receptors B) ~bly of the chamin COA P"ching " off of the vision the membrane transport of vesicles along microtubules. Which of the following events does not occur in the rough endoplasmic reticulum? Cleavage of the signal peptide by the signal peptidase. Binding of chaperone proteins to misfolded partially folded proteins. Accharyl transfera C) Transfer of pro-formed oligosaccharides to proteins. Degradation of misfolded proteins by the ubiquitin-proteasome system. Formation of vesicles destined for the Golgi apparatus. Which of the following elements is not required for transport of a soluble endoplasmic reticulum (ER) protein? A) ER signal sequence. B) Protein translocator. C) Signal recognition particle receptor. D) Stop transfer sequence. Your friend works at a biotechnology company and has discovered a drug that blocks GTP exchange GDP for GTP. What is the most likely effect of this drug on nuclear transport? A) Nuclear transport receptors would be unable to bind cargo. B) Nuclear transport receptors would be unable to enter the nucleus. C) Nuclear transport receptors would be unable to release their cargo in the nucleus. D) Nuclear transport receptors would interact irreversibly with the nuclear pore fibrils. The packaging of proteins into secretory vesicles occurs in discrete steps. Which of the following describes the correct order of the events listed in I-IV below? I. The GTPase Dynamin pinches off the vesicle from the membrane of origin. II. Clathrin binds to adaptin. III. Clathrin coat falls off. IV. Cargo receptor binds cargo. A) I, III, IV. B) I, II, IV, III. C) IV, III. D) IV, II, III.
Sri K.
(d) Golgi → lysosome → plasma membrane 24. Which pair of proteins helps vesicles dock at their target membranes? (a) dynamin/clathrin (c) v-SNARE/t-SNARE (b) adaptin/clathrin (d) SRP/SRP receptor 25. Which of the following is not required for protein transport into the mitochondria? (a) signal sequence (c) import receptor (b) Ran GTPase (d) protein translocator 26. The protein required for vesicles to pinch off from the parent membrane is (a) adaptin (c) clathrin (b) dynamin (d) flippase 27. In which cellular location would you expect to find ribosomes translating mRNAs that encode ribosomal proteins? (a) in the nucleus (c) on the rough ER (b) in the cytosol (d) in the lumen of the ER 28. The Na+ channel involved in transmitting neuronal signal along axon is (a) ligand-gated (c) Stress-gated (b) voltage-gated (d) none of the above 29. The Na+-K+ pump is an example of which of the following? (a) uniport (c) antiport (b) symport (d) none of the above 34. The resting membrane potential for most animal cells is 0 mV (a) true (b) false 35. The Na+-K+ pump is responsible for maintaining the high extracellular Na+ concentration and the high intracellular K+ concentration. (a) true (b) false 36. Proteins that are misfolded are degraded in the ER lumen (a) true (b) false 37. Most proteins destined to enter the endoplasmic reticulum begin to cross the membrane while still being synthesized. (a) true (b) false 38. Some of the proteins in the lumen of the ER can end up in the plasma membrane. (a) true (b) false 39. Signal sequences that direct proteins to the correct compartment are encoded in the amino acid sequence and sufficient for targeting a protein to its correct destination. (a) true (b) false 40. Proteins that are translated in the cytosol and lack a sorting signal will end up in the cytosol. (a) true (b) false
Adi S.
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