00:01
For this question, we are going to look at an amino acid cheat sheet i made in order to remember the characteristics of all the amino acids to best answer this question.
00:12
So our question is which two amino acids are most likely to be located in the hydrophobic core of a globular protein, not contacting water.
00:22
So again, what we have in this question is that it's a hydrophobic core, which is a characteristic of this globular protein.
00:31
And it's not, doesn't want to be in contact with water.
00:36
So are we looking for an acidic, basic, non -polar, polar, or sulfur type of amino acid? well, let's go through them.
00:45
So an acid or a base, those are things that are able to react and do cool things with water, but also each other.
00:54
Those probably are going to be near the outside so they can do a lot of cool things and react.
00:59
Proline is a unique case.
01:01
We won't talk about it for this question.
01:04
So non -polar amino acids side chains are going to be the amino acids, which usually don't do much, and they are usually hydrophobic, meaning they don't like to react with water.
01:17
So these are great contenders for things that would be inside a protein and not wanting to react with water.
01:26
Polar.
01:27
So water is a polar molecule we know polar likes polar.
01:30
So these are going to be great reactors with water and they're probably going to be on the outside of a protein so that they can do their job and act with water.
01:39
Sulfur containing, we will not talk about those amino acids for this question.
01:44
So really, after all the amino acids we've looked at them, our non -polar amino acids are the ones that we are trying to find in this question because the non -polar amino acids are going to be the amino acids which are best at being hydrophobic and would love to be inside of a protein away from water and hiding in there...