Question
Many enzymes are active only in the presence of $\mathrm{Zn}^{2+}$ What common term is used for ions such as $\mathrm{Zn}^{2+}$ when discussing enzyme activity?
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Step 1: Firstly, we need to understand that $\mathrm{Zn}^{2+}$ is required for the activity of more than 300 enzymes, covering all six classes of enzymes. Show more…
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Some enzymes require certain metal ions, such as Mg2+ or Zn2+, in order to have full activity. This component is called a:
Carboxypeptidase $A,$ a $Z n^{2+}$ -containing enzyme, hydrolyzes the C-terminal peptide bonds of polypeptides (Fig $8-19 a$ ). In the enzyme-substrate complex, the $\mathrm{Zn}^{2+}$ ion is coordinated to three enzyme side chains, the carbonyl oxygen of the scissile peptide bond, and a water molecule. A plausible model for the enzyme's reaction mechanism that is consistent with X-ray and enzymological data is diagrammed in Fig. $15-42 .$ What are the roles of the $\mathrm{Zn}^{2+}$ ion and Glu 270 in this mechanism?
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