Which of the following best explains the direct impact of statins on cholesterol metabolism?
Question 10 options:
They stimulate thiolase, thus making more malonyl-CoA for inhibition of the tricarboxylic acid cycle.
They inhibit HMG-CoA synthase, a key step for the synthesis of mevalonate that inhibits fatty acid synthesis.
They bind to low-density lipoprotein (LDL) receptors, displacing cholesterol and inhibiting cholesterol synthesis.
They stimulate the synthesis of trans-unsaturated fatty acids.
They inhibit 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, a key regulator of cholesterol synthesis.