11. Which of the following residues would most likely be buried in the interior of a water soluble, globular protein? a. Asp b. Ser c. Lys d. Phe e. Gln 12. In the ?-helix, the hydrogen bonds: a. are roughly parallel to the axis of the helix b. are roughly perpendicular to the axis of the helix c. occur mainly between electronegative atoms of the R groups d. occur mainly between some of the amino acid residues of the helix e. occur near the amino and carboxyl termini of the helix 13. Which of the following statements does not apply to collagen? a. It contains hydroxylated amino acids. b. The polypeptide forms a left-handed helix. c. Hydrogen bonds between the —OH groups of 4-hydroxyproline residues stabilize the helix. d. There is an absolute requirement for Gly every third position. e. The triple helical structure twists in the right-handed direction. 14. A D-amino acid residue would interrupt an ?-helix made of L-amino acid residues. Another naturally occurring hindrance to the formation of an ?-helix is the presence of: a. a negatively charged Arg residue. b. a nonpolar residue near the carboxyl terminus. c. a positively charged Lys residue. d. a Pro residue. e. two Ala residues next to each other.
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Phe. Reasoning: Water-soluble globular proteins bury hydrophobic side chains in their interior to avoid contact with water. Phenylalanine (Phe) has a large nonpolar aromatic side chain and is therefore the most likely to be buried. Asp, Ser, Lys, and Gln are polar Show more…
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11. Which of the following residues would most likely be buried in the interior of a water soluble, globular protein? a. Asp b. Ser c. Lys d. Phe e. Gln 12. In the ̑-helix, the hydrogen bonds: a. are roughly parallel to the axis of the helix b. are roughly perpendicular to the axis of the helix c. occur mainly between electronegative atoms of the R groups d. occur mainly between some of the amino acid residues of the helix e. occur near the amino and carboxyl termini of the helix 13. Which of the following statements does not apply to collagen? a. It contains hydroxylated amino acids. b. The polypeptide forms a left-handed helix. c. Hydrogen bonds between the —OH groups of 4-hydroxyproline residues stabilize the helix. d. There is an absolute requirement for Gly every third position. e. The triple helical structure twists in the right-handed direction. 14. A D-amino acid residue would interrupt an ̑-helix made of L-amino acid residues. Another naturally occurring hindrance to the formation of an ̑-helix is the presence of: a. a negatively charged Arg residue. b. a nonpolar residue near the carboxyl terminus. c. a positively charged Lys residue. d. a Pro residue. e. two Ala residues next to each other.
Sri K.
19. Which of the following amino acid residues would most likely be found in the interior of a globular protein? A. glutamic acid B. leucine C. lysine D. serine E. arginine 20. A sigmoidal binding curve for molecule X to a certain protein, Y suggests that A. Binding affinity between X and Y is weak. B. Binding affinity between X and Y is strong. C. Binding between X and Y shows cooperativity. D. One molecule of Y binds more than one molecule of X. E. More than one molecule of Y is needed to bind each molecule of X. 21. What feature does a Ramachandran plot display? A. Allowed angles of rotation of peptide planes. B. Preferred amino acids in an α-helix. C. The hydropathic index of amino acids. D. The variation of pH versus volume of base added during titration to determine the pKa. E. The order in which proteins are eluted from an ion exchange or gel filtration column. 22. Which statement is not true about the peptide bond? A. The peptide bond has partial double-bond character. B. The peptide bond is an amide bond. C. The peptide bond is longer than the typical carbon-nitrogen bond. D. Rotation is restricted about the peptide bond. E. The C-O and N-H are most often in a trans configuration with respect to one another.
The amino acid residue that would LEAST likely be buried in the interior of a water-soluble globular protein is: lysine. tyrosine phenylalanine. methionine isoleucine What would be the overall charge of the peptide Asp-Ala-Arg-His at pH 4? 3 0 2 –1 1 Citric acid is an important intermediate in glucose metabolism and is synthesized in the mitochondrial matrix. The pKa values for each of the three carboxylic groups of the citric acid are 3.1, 4.8, and 6.4. What is the charge on a citrate molecule formed in the mitochondrial matrix where the pH is 5.8? –3 +2 –2 +1 +3 Which amino acids would be most soluble in a nonpolar solvent such as toluene? threonine Leucine histidine glutamine glycine Which statements about the polypeptide Ser-Tyr-Gly-Phe-Met-Gly are CORRECT? Select all that apply. Serine is the N-terminal residue. Glycine is the C-terminal residue. Glycine is the N-terminal residue. Methionine is the N-terminal residue. Serine is the C-terminal residue
Keemin L.
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