+678pes /1600 Question 13 of 16 The amino acid asparagine is required by cancer cells to proliferate. ETreating patients with the enzyme asparaginase is sometimes used as a chemotherapy treatment. Asparaginase hydrolyzes asparagine సo aspartate and ammonia. The adjoining illustration shows the 5 Michaelis-Menten curves for two asparaginases from different Qsources, as well as the concentration of asparagine in the environment (indicated by the arrow). Which enzyme would make a better chemotherapeutic agent? ◻ asparaginase 1 ◻ asparaginase 2 ◻ Both enzymes would likely work equally well. ◻ It cannot be determined.
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$K_{\mathrm{M}}$ matters. The amino acid asparagine is required by cancer cells to proliferate. Treating patients with the enzyme asparaginase is sometimes used as a chemotherapy treatment. Asparaginase hydrolyzes asparagine to aspartate and ammonia. The adjoining illustration shows the MichaelisMenten curves for two asparaginases from different sources, as well as the concentration of asparagine in the environment (indicated by the arrow). Which enzyme would make a better chemotherapeutic agent? (TABLE CANNOT COPY)
Treating patients with the enzyme Asparaginase is sometimes used as a chemotherapy treatment. Km as a predictor of enzyme function. M-M curve for two Asparaginase from different sources. Asn Asp + NH4 Asparaginase A. Which enzyme would make a better Asparaginase B chemotherapeutic agent? 0.2 0.4 0.6 0.8 1 1.2 1.4 [Asn] (x 10-6 M) [Asn] in the cell.
Adi S.
Certain tumors can not synthesize the amino acid L-asparagine and must obtain it from the blood. One treatment for these tumors involves an intravenous (IV) injection of the enzyme, L-asparaginase which hydrolyzes L-asparagine to aspartate and thereby lowers the blood concentration of asparagine. However, to be effective, the injected asparaginase must be able to maintain blood asparagine at a concentration of less than 2 μM. Which of the following variants of asparaginase in the table below would be the most effective for therapeutic use? Km (μM) Vmax (μmoles/min/mg) Asparginase-1 0.25 5 Asparginase-2 0.5 5 Asparginase-3 1.0 10 Asparginase-4 2.0 20
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