Question

A mutation that altered a single nucleotide within the anti-codon of a tRNA molecule could be expected to have which of the following consequences? The polypeptide amino acid sequence could be altered due to an incorrect amino acid bound to the mutant tRNA. This would be less likely to affect the amino acid sequence if the mutation occurred on nucleotide 1 or 2 of the anti-codon. The polypeptide amino acid sequence could be altered due to incorrect base-pairing between the mutant tRNA and mRNA codons. More than one option is possible. 

          A mutation that altered a single nucleotide within the
anti-codon of a tRNA molecule could be expected to have which of
the following consequences?
The polypeptide amino acid sequence could be altered due to an
incorrect amino acid bound to the mutant tRNA.
This would be less likely to affect the amino acid sequence if
the mutation occurred on nucleotide 1 or 2 of the
anti-codon. 
The polypeptide amino acid sequence could be altered due to
incorrect base-pairing between the mutant tRNA and mRNA codons.
More than one option is possible.
Show more…

Added by Jeffery B.

Biology for AP Courses
Biology for AP Courses
Julianne Zedalis, John Eggebrecht
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A mutation that altered a single nucleotide within the anti-codon of a tRNA molecule could be expected to have which of the following consequences? The polypeptide amino acid sequence could be altered due to an incorrect amino acid bound to the mutant tRNA. This would be less likely to affect the amino acid sequence if the mutation occurred on nucleotide 1 or 2 of the anti-codon. The polypeptide amino acid sequence could be altered due to incorrect base-pairing between the mutant tRNA and mRNA codons. More than one option is possible.
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A mutation in DNA generates a UGA stop codon in the middle of the mRNA coding for a particular protein. A second mutation in the cell's DNA leads to a single nucleotide change in a tRNA that allows the correct translation of the protein; that is, the second mutation "suppresses" the defect caused by the first. The altered tRNA translates the UGA as tryptophan. What nucleotide change has probably occurred in the mutant tRNA molecule? What consequences would the presence of such a mutant tRNA have for the translation of the normal genes in this cell?

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Transcript

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00:01 Hello students in this question we have been told that our t rna nucleotide is changed what will be the effect of this on the polypeptide so this is the anticoad on end of the t rna so there are three nucleotides n2 and end and 3 okay the numbering is from here n3 n2 and n1 and say this is the mrna so this is codon 1 so this is 1 codon and this is base 1 base 2 and base 3 so what happens during the binding of anticodon to the codon is that the n3 of the anticodon that is the base third of the anticodon will bind to the first base of the the codon of the mrna.
01:16 So if say there is a mutation that the nucleotide has been changed because of this what happens is the nucleotide that it was supposed to sorry the amino acid that it was supposed to carry would be changed.
01:35 So this is one possibility but what happens to the basis the complementary pair that we see has a lot of times that the first anticoidon is more important compared to the second and the third.
01:52 The third does not play a significant role but the second sometimes can have an effect but the first one is very important...
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