00:01
Hi, this question is related to the micro leads.
00:14
So the mechanism of action of micro leads revolves around their ability to bind the bacterial 50s ribosomal subunit causing the cessation of the bacterial protein synthesis.
01:36
So the next that is question from 2.
01:44
That is elongation in the bacterial translation.
02:01
It involves the peptideal bond formation between the two amino acid or add the addition of new amino acid to growth of polypeptide chain.
02:52
So this peptide bond reaction is catalyzed by 23 sr rna in the the 50s subunit of bacterial ribosome.
03:28
So erythromycin is an antibiotic, is an antibiotic which inhibit the bacterial growth by interfere with the elongation step of bacterial translation.
04:22
So this antibiotic binds with the 50s subunit of ribosome and involving protein synthesis and interferes with the translation of rna from a site to the e site to p side to p site in ribosomal complex.
04:52
This inhibit the binding of new t rna carrying out amino acid to enter the ribosomal complex thereby no new amino acid attachment to the growing polypeptide.
05:03
This results in the failure of functional protein formation.
05:23
This is the reason behind bacteriostatic activity of erythromycin...
