Question

A biopsy was performed on a patient presented with jaundice and with history of heavy alcohol intake. Biochemical tests showed abnormal liver function. H&E staining was carried out and the image is shown below. Hepatic lobules can be noted. The white spaces are indicative of abnormal liver architecture. Other staining methods can be performed to further evaluate the abnormal hepatic change. 1) Name one confirmatory special staining method that can be conducted to determine the nature of fatty change and fibrosis of hepatocytes. 2) What structures would be visible with further special staining technique. 3) Briefly describe the result of special staining. 4) Explain the limitations of H&E staining as confirmatory staining of hepatocytes in this case. (6 marks)

          A biopsy was performed on a patient presented with jaundice and with history of heavy alcohol intake. Biochemical tests showed abnormal liver function. H&E staining was carried out and the image is shown below. Hepatic lobules can be noted. The white spaces are indicative of abnormal liver architecture.

Other staining methods can be performed to further evaluate the abnormal hepatic change. 1) Name one confirmatory special staining method that can be conducted to determine the nature of fatty change and fibrosis of hepatocytes. 2) What structures would be visible with further special staining technique. 3) Briefly describe the result of special staining. 4) Explain the limitations of H&E staining as confirmatory staining of hepatocytes in this case. (6 marks)

A biopsy was performed on a patient presented with jaundice and with history of heavy alcohol intake. Biochemical tests showed abnormal liver function. H E staining was carried out and the image is shown below. Hepatic lobules can be noted. The white spaces are indicative of abnormal liver architecture.

Other staining methods can be performed to further evaluate the abnormal hepatic change. 1) Name one confirmatory special staining method that can be conducted to determine the nature of fatty change and fibrosis of hepatocytes. 2) What structures would be visible with further special staining technique. 3) Briefly describe the result of special staining. 4) Explain the limitations of H E staining as confirmatory staining of hepatocytes in this case. (6 marks)

Added by Salvador S.

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