A 50-year-old man presented to the ER with jaundice and ascites. He has been a heavy alcohol user on and off for approximately 15 years, and 2 years ago he started drinking between a pint and a quart of vodka daily. CT scans show decreased density of the liver suggestive of liver steatosis (fat accumulation in the liver). At the molecular level, what may be wrong with this patient? Answers A - E A Decreased synthesis of ApoB100 B Accumulation of chylomicron remnants C Decreased synthesis of ApoB48 D Decreased synthesis of ApoE E Defective liver bile salts synthesis
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The CT scan shows liver steatosis, which is the accumulation of fat in the liver. This condition is commonly associated with alcohol abuse. At the molecular level, one possible issue with this patient could be related to the synthesis of apolipoproteins, which Show more…
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A 50-year-old man presented to the ER with jaundice and ascites. He has been a heavy alcohol user on and off for approximately 15 years, and 2 years ago he started drinking between a pint and a quart of vodka daily. CT scans show decreased density of the liver suggestive of liver steatosis (fat accumulation in the liver). At the molecular level, what may be wrong with this patient? Answers: 1. Decreased synthesis of ApoB100 2. Accumulation of chylomicron remnants 3. Decreased synthesis of ApoB48 4. Decreased synthesis of ApoE 5. Defective liver bile salts synthesis
Adi S.
A 55-year-old man comes to the physician for a follow-up visit after his liver function tests showed abnormal findings. He has no history of hepatic disease. He has consumed two to four alcoholic beverages daily for 25 years, but he has been drinking nearly twice that amount during the past 2 months. He has a history of stage IIB colon cancer 3 years ago that was successfully treated with resection and adjuvant chemotherapy. His pulse is 66/min, respirations are 12/min, and blood pressure is 135/72 mm Hg. Abdominal examination shows a palpable liver just below the right costal margin. Serum studies show: Albumin 3.1 g/dL Total bilirubin 1.5 mg/dL Alkaline phosphatase 250 U/L AST 110 U/L ALT 65 U/L Ultrasonography of the liver shows five nodules that vary in size from 1.5 to 2.5 cm. A photomicrograph of a biopsy specimen of the lesion is shown. Which of the following is the most likely diagnosis? A) Alcoholic steatohepatitis B) Cirrhotic nodule C) Hepatic adenoma D) Hepatocellular carcinoma E) Metastatic adenocarcinoma
Asma V.
A biopsy was performed on a patient presented with jaundice and with history of heavy alcohol intake. Biochemical tests showed abnormal liver function. H&E staining was carried out and the image is shown below. Hepatic lobules can be noted. The white spaces are indicative of abnormal liver architecture. Other staining methods can be performed to further evaluate the abnormal hepatic change. 1) Name one confirmatory special staining method that can be conducted to determine the nature of fatty change and fibrosis of hepatocytes. 2) What structures would be visible with further special staining technique. 3) Briefly describe the result of special staining. 4) Explain the limitations of H&E staining as confirmatory staining of hepatocytes in this case. (6 marks)
Madhur L.
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