Endocrinology (Select the INCORRECT statement) * Thyroid hormone is a derivative of the amino acid tyrosine. Thyroid hormone is stored in an extracellular compartment. Steroid hormones may act via an intracrine mechanism, meaning that they have the potential to bind to a receptor that is present within the same cell in which the steroid was synthesized. Autacoids are peptides that are made-on-demand and act in an autocrine or paracrine fashion. Prostaglandins are lipophilic signaling molecules.
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Explain the histology of the thyroid gland, how thyroid hormone is synthesized in the epithelial cells of the follicle, such as the iodine trap, the hypothalamus-adenohypophysis-thyroid gland axis and negative feedback regulation, the regulation using iodine, the intracellular signaling pathways within the adenohypophysis and the thyroid gland, autoregulation of thyroid hormone production, factors regulating thyroid hormone levels, actions of thyroid hormones, mechanism of action of thyroid hormone (TRE-receptor interaction, coactivators, corepressors), major genes whose expression is changed (e.g., Na+/K+-ATPase), the major actions of thyroid hormone across major organ systems (e.g., nervous, CV, pulmonary, renal).
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