For the hydrolysis of atp to adp + i, the free energy change is -7.3 kcal/mol under standard conditions (1 m concentration of both reactants and products). in the cellular environment, however, the free energy change is about -13 kcal/mol. what can we conclude about the free energy change for the formation of atp from adp and i under cellular conditions?
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Step 1: In the cellular environment, the free energy change for the hydrolysis of ATP to ADP + Pi is -13 kcal/mol, which means energy is released during this reaction. Show more…
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Environmental conditions. The standard free energy of hydrolysis for ATP is $-30.5 \mathrm{kJ} \mathrm{mol}^{-1}\left(-7.3 \mathrm{kcal} \mathrm{mol}^{-1}\right)$ $$\mathrm{ATP}+\mathrm{H}_{2} \mathrm{O} \rightleftharpoons \mathrm{ADP}+\mathrm{P}_{\mathrm{i}}$$ What conditions might be changed to alter the free energy of hydrolysis?
The free energy change for ATP hydrolysis is -30.5 kJ/mol under standard conditions, but the actual free energy of hydrolysis (ΔG'°) of ATP in living cells is very different because the cellular concentrations of ATP, ADP, and Pi are not identical and are much lower than the 1.0 M of standard conditions. The actual free energy of hydrolysis of ATP under intracellular conditions is often called its phosphorylation potential, ΔGp. Calculate the actual free energy of hydrolysis of ATP, ΔGp, in human erythrocytes at pH 7.0 and the temperature 37°C (body temp). The concentrations of ATP, ADP, and Pi in human erythrocytes are 2.25, 0.25, and 1.65 mM, respectively. Hint: ΔGp = ΔG'° + RT ln [ADP][Pi]/[ATP] What does this reveal about the amount of energy required to synthesize ATP under the physiological conditions?
Sri K.
Calculate the actual free energy change for the hydrolysis of ATP in human cells. In humans, the concentrations of ATP, ADP, and Pi are 2.25, 0.25, and 1.65 mM, respectively. Let us assume that the pH is 7.0 and the temperature is 37°C. In our cells, is this reaction at equilibrium? Justify your answer and discuss how the concentrations affect the free energy for this reaction. Are our bodies systems at equilibrium?
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