Use the table below to determine which of the sequences of...

Use the table below to determine which of the sequences of nucleotides below in the template strand of DNA would code for the polypeptide sequence phe-leu-ile-val. Second Base U C A G UUU UCU UAU UGU U Phe Tyr Cys UUC UCC UAC UGC C U Ser UUA UCA UAA Stop UGA Stop A Leu UUG UCG UAG Stop UGG Trp G CUU CCU CAU CGU U His CUC CCC CAC CGC C First Base C Leu Pro Arg CUA CCA CAA CGA A Gln CUG CCG CAG CGG G Third Base AUU ACU AAU AGU U Asn Ser AUC Ile ACC AAC AGC C A Thr AUA ACA AAA AGA A Lys Arg AUG Met or Start ACG AAG AGG G GUU GCU GAU GGU U Asp GUC GCC GAC GGC C G Val Ala Gly GUA GCA GAA GGA A Glu GUG GCG GAG GGG G

Transcript

00:01 Here we have some different dna sequences in the template strand, and we're looking for one that is going to give us therionine, lysine, cyrian, lysine.

00:13 Okay, we have four possibilities.

00:16 How do we work out which of them will give us this amino acid sequence? well, we have to follow the steps of protein synthesis.

00:23 First of all, transcription and then translation.

00:26 So transcription will give us a complementary mrna sequence.

00:33 So we have to remember the base pairing rules as so.

00:38 Cytocene to guanine, guanine to cytosine, aden to either thymine or urosil.

00:43 Thymine and dna, uracil in rna.

00:47 So we're going to transcribe each of these sequences, and then we need to translate them.

00:52 So another thing we need to remember is that nucleic acids are always anti -parallel.

00:57 So if you have one sequence that goes 5 prime to 3 prime and you want to make the complementary sequence, complementary sequence will go 3 prime to 5 prime like so.

01:14 So we need to remember that as well.

01:19 And in translation, all we need to do is remember that codons are read 5 -friam to 3 -prime, and we use the codon chart to work out what amino acids there are.

01:29 So let's start with our first dna sequence and follow these steps.

01:32 So the dna sequence starts at 3 prime, so the mrna will start 5 prime, and i'm just going to go through and put in the complementary sequence here.

01:49 So it starts at tgg, which is going to be a -c -c, a -g -u, g -g -u.

02:02 And that goes to 3 -prime.

02:06 Okay.

02:06 Now i'm going to use the codon chart to see what amino acids v correspond to.

02:11 So acc is our first one, and acc is brinine.

02:17 Good start.

02:18 A .a .a .a.

02:20 Is lysine.

02:21 Okay...

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