Question

Sickle-Cell Anemia is an inherited red blood cell (RBC) disorder in which there aren't enough healthy blood cells to carry oxygen throughout your body. The disease causes aggregation of hemoglobin (Hb), the protein responsible for oxygen transport in RBCs. When Hb aggregates, it causes the formation of long, rigid polymer-esque rods of protein in RBCs. These rods cause the shape of normally round, flexible RBCs to instead sickle, preventing them from moving easily through blood vessels. Nucleotides 1-18 of the WT Hb gene are seen below. Sickle-cell anemia is caused by an A -> T mutation at position 14. 5' - GTCCACACTCCTGAGGAG - 3'. What is the resulting amino acid sequence of the WT Hb protein? What is the resulting amino acid sequence of the mutated Hb protein?

          Sickle-Cell Anemia is an inherited red blood cell (RBC) disorder in which there aren't enough healthy blood cells to carry oxygen throughout your body. The disease causes aggregation of hemoglobin (Hb), the protein responsible for oxygen transport in RBCs. When Hb aggregates, it causes the formation of long, rigid polymer-esque rods of protein in RBCs. These rods cause the shape of normally round, flexible RBCs to instead sickle, preventing them from moving easily through blood vessels. Nucleotides 1-18 of the WT Hb gene are seen below. Sickle-cell anemia is caused by an A -> T mutation at position 14. 5' - GTCCACACTCCTGAGGAG - 3'. What is the resulting amino acid sequence of the WT Hb protein? What is the resulting amino acid sequence of the mutated Hb protein?

Added by Robert H.

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