Question

The following 5'-3' molecule is the beginning of a newly transcribed messenger RNA sequence. Translate the initial mRNA sequence, listing the three-letter amino acid polypeptide, and then translate each of the sequences generated by mutations to this initial sequence (parts b-c). State the kind of mutation that results for each sequence. 5'---CAGUAUGCCAUGGGGUCGAUGAGGCU---3' a) Translation of original sequence: b) Translate the initial mRNA sequence, adding a U between the 2 Cs at position 4. Translation Amino acid sequence Name of mutation c) Translate the initial mRNA sequence, changing the G at position 3 to an A. Translation Amino acid sequence Name of mutation Second base of RNA codon U C A G UUU Phe UCU UAU Tyr UGU Cys U UUC UCC UAC UGC C UUA Leu UCA Ser UAA Stop UGA Stop A UUG UCG UAG Stop UGG Trp G CUU CCU CAU His CGU U CUC Leu CCC CAC CGC C CUA CCA Pro CAA Gln CGA Arg A CUG CCG CAG CGG G AUU ACU AAU Asn AGU Ser U AUC Ile ACC AAC AGC C AUA ACA Thr AAA Lys AGA Arg A AUG Met or start ACG AAG AGG G GUU GCU GAU Asp GGU U GUC Val GCC Ala GAC GGC Gly C GUA GCA GAA Glu GGA A GUG GCG GAG GGG G

          The following 5'-3' molecule is the beginning of a newly transcribed messenger RNA sequence. Translate the initial mRNA sequence, listing the three-letter amino acid polypeptide, and then translate each of the sequences generated by mutations to this initial sequence (parts b-c). State the kind of mutation that results for each sequence.

5'---CAGUAUGCCAUGGGGUCGAUGAGGCU---3'

a) Translation of original sequence:
b) Translate the initial mRNA sequence, adding a U between the 2 Cs at position 4.
Translation
Amino acid sequence
Name of mutation
c) Translate the initial mRNA sequence, changing the G at position 3 to an A.
Translation
Amino acid sequence
Name of mutation

Second base of RNA codon
U C A G
UUU Phe UCU UAU Tyr UGU Cys U
UUC UCC UAC UGC C
UUA Leu UCA Ser UAA Stop UGA Stop A
UUG UCG UAG Stop UGG Trp G

CUU CCU CAU His CGU U
CUC Leu CCC CAC CGC C
CUA CCA Pro CAA Gln CGA Arg A
CUG CCG CAG CGG G

AUU ACU AAU Asn AGU Ser U
AUC Ile ACC AAC AGC C
AUA ACA Thr AAA Lys AGA Arg A
AUG Met or start ACG AAG AGG G

GUU GCU GAU Asp GGU U
GUC Val GCC Ala GAC GGC Gly C
GUA GCA GAA Glu GGA A
GUG GCG GAG GGG G

The following 5'-3' molecule is the beginning of a newly transcribed messenger RNA sequence. Translate the initial mRNA sequence, listing the three-letter amino acid polypeptide, and then translate each of the sequences generated by mutations to this initial sequence (parts b-c). State the kind of mutation that results for each sequence.

5'—CAGUAUGCCAUGGGGUCGAUGAGGCU—3'

a) Translation of original sequence:
b) Translate the initial mRNA sequence, adding a U between the 2 Cs at position 4.
Translation
Amino acid sequence
Name of mutation
c) Translate the initial mRNA sequence, changing the G at position 3 to an A.
Translation
Amino acid sequence
Name of mutation

Second base of RNA codon
U C A G
UUU Phe UCU UAU Tyr UGU Cys U
UUC UCC UAC UGC C
UUA Leu UCA Ser UAA Stop UGA Stop A
UUG UCG UAG Stop UGG Trp G

CUU CCU CAU His CGU U
CUC Leu CCC CAC CGC C
CUA CCA Pro CAA Gln CGA Arg A
CUG CCG CAG CGG G

AUU ACU AAU Asn AGU Ser U
AUC Ile ACC AAC AGC C
AUA ACA Thr AAA Lys AGA Arg A
AUG Met or start ACG AAG AGG G

GUU GCU GAU Asp GGU U
GUC Val GCC Ala GAC GGC Gly C
GUA GCA GAA Glu GGA A
GUG GCG GAG GGG G

Added by William P.

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