Which of the following is NOI required for male sex differentiation? ◻ Wht4 Sox9 AMH Sry DHT
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Male sex differentiation is primarily influenced by specific genes and hormones that lead to the development of male reproductive structures. Show more…
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10. Indicate which of the six organs (i-vi) would be present at birth in each individual listed below (a-d). Note: the androgen receptor gene is X-linked. The 5α-reductase gene is autosomal: i. testis ii. ovaries iii. male internal sex organs (e.g., the prostate) iv. female internal sex organs (e.g., the uterus) v. male external sex organs (e.g., the penis) vi. female external sex organs (e.g., the clitoris) a. XY individual hemizygous for a nonfunctional allele of the androgen receptor gene. b. XX individual homozygous for nonfunctional alleles of the androgen receptor gene. c. XY individual with a nonfunctional allele of the SRY gene. d. XY individual homozygous for nonfunctional alleles of the 5α-reductase gene.
Dominador T.
1. Name the gene that is responsible for the development of testes (i.e., differentiation of the gonadal ridges into testes) in the genetic (XY) male? 2. Name the substance (hormone) secreted by Sertoli cells that is responsible for degeneration of the female (paramesonephric or Mullerian) duct in the male fetus? 3. Name the male and female structures that form from the genital tubercle and labioscrotal swelling. 4. What happens to a genetic male fetus if the testes are not producing testosterone? 5. What happens to a genetic male fetus if the testes are not producing MIH?
Adi S.
1. Describe, from fertilization, the major pathways of normal male sex development. Include the stages in which genetic sex, gonadal sex, and phenotypic sex are determined. 2. Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (Wolffian or Muellerian ducts, external genitalia), and (3) are sterile or fertile. a) XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone. b) XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone. 3. Calico cats are almost invariably female. Why? (Hint: explain the genotype and phenotype of calico females) 4. How many Barr bodies would the following individuals have? a) Normal male b) Normal female c) Klinefelter male d) Turner female
Josee P.
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