Which of the following mutations is likely to prevent cell-cycle progression? Select one: a. A mutation that prevented binding of Rb to E2F. b. A mutation that destroyed the normal activity of p53 c. A mutation that allowed the kinase which phosphorylates Ras to be active independent of its phosphorylation status. d. A mutation in a cell-surface EGF receptor that made it active even in the absence of its mitogen ligand. e. A mutation that removed the amino acid serine that can be phosphorylated by Cdks on the Rb protein.
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A mutation that prevented binding of Rb to EZF: Rb is a tumor suppressor protein that inhibits cell cycle progression. If it cannot bind to EZF, it may not be able to perform its inhibitory function, leading to uncontrolled cell cycle progression. b. A mutation Show more…
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